Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain.

ABSTRACT: Around 20% of the American population have chronic pain and estimates in other Western countries report similar numbers. This represents a major challenge for global health care systems. Additional problems for the treatment of chronic and persistent pain are the comparably low efficacy of existing therapies, the failure to translate effects observed in preclinical pain models to human patients and related setbacks in clinical trials from previous attempts to develop novel analgesics. Drug repurposing offers an alternative approach to identify novel analgesics as it can bypass various steps of classical drug development. In recent years, several approved drugs were attributed analgesic properties. Here, we review available data and discuss recent findings suggesting that the approved drugs

SUBMITTER: Sisignano M 

PROVIDER: S-EPMC8899787 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature