Obstructive Sleep Apnea Affects Lacrimal Gland Function.

ABSTRACT:

Purpose

To determine the effect of obstructive sleep apnea syndrome (OSA) on lacrimal gland function and its mechanism.

Methods

Male mice aged seven to eight weeks were housed in cages with cyclic intermittent hypoxia to mimic OSA, and the control group was kept in a normal environment. Slit-lamp observation, fluorescein staining, and corneal sensitivity detection are used to assess cornea changes. Tear secretion was detected by phenol red cotton thread, and the pathological changes of lacrimal gland were observed by hematoxylin and eosin staining, oil red O staining, cholesterol and triglyceride kits, immunofluorescence staining, immunohistochemical staining, real-time polymerase chain reaction, transmission electron microscopy, and Western blot.

Results

Studies reve

SUBMITTER: Wang S 

PROVIDER: S-EPMC8899859 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature