Decreased RNA m⁶A methylation enhances the process of the epithelial mesenchymal transition and vasculogenic mimicry in glioblastoma.

ABSTRACT: RNA N⁶-methyladenosine (m⁶A) modification is gradually thought to be an active participant in the considerable biological processes of glioblastoma (GB), providing us with a novel insight for exploring this disease. However, the role of RNA m⁶A modification during the epithelial mesenchymal transition (EMT) or vasculogenic mimicry (VM) progression has not been investigated in GB. Here we performed a research to validate the impact exerted by AlkB homolog 5 (ALKBH5), one of "erasers" for RNA m⁶A and methyltransferase-like 3 (METTL3) which adds m⁶A modification to the RNAs on the progression of EMT and VM in GB. In this study, we demonstrate that the m⁶A levels of RNAs were reduced in GB cells and glioma tissues. Patients with

SUBMITTER: Tao M 

PROVIDER: S-EPMC8899976 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature