Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.

ABSTRACT:

Objectives

Investigating the effect of prognostic factors in a multistate framework on survival in a large population of patients with osteosarcoma. Of interest is how prognostic factors affect different disease stages after surgery, with stages of local recurrence (LR), new metastatic disease (NM), LR+NM, secondary malignancy, a second NM, and death.

Design

An open-label, international, phase 3 randomised controlled trial.

Setting

325 sites in 17 countries.

Participants

The subset of 1631 metastases-free patients from 1965 patients with high-grade resectable osteosarcoma, from the European and American Osteosarcoma Study.

Main outcome measures

The effect of prognostic factors on different disease stages, expressed as HRs; predictions of disease progress

SUBMITTER: Hazewinkel AD 

PROVIDER: S-EPMC8900028 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature