OMARU: a robust and multifaceted pipeline for metagenome-wide association study.

ABSTRACT: Microbiome is an essential omics layer to elucidate disease pathophysiology. However, we face a challenge of low reproducibility in microbiome studies, partly due to a lack of standard analytical pipelines. Here, we developed OMARU (Omnibus metagenome-wide association study with robustness), a new end-to-end analysis workflow that covers a wide range of microbiome analysis from phylogenetic and functional profiling to case-control metagenome-wide association studies (MWAS). OMARU rigorously controls the statistical significance of the analysis results, including correction of hidden confounding factors and application of multiple testing comparisons. Furthermore, OMARU can evaluate pathway-level links between the metagenome and the germline genome-wide as

SUBMITTER: Kishikawa T 

PROVIDER: S-EPMC8900191 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature