Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments.

ABSTRACT:

Objective

Febrile seizures (FSs) are the most common form of seizures in children. Single short FSs are benign, but FSs lasting longer than 30 min, termed febrile status epilepticus, may result in neurological sequelae. However, there is little information about an intermediary condition, brief recurrent FSs (RFSs). The goal of this study was to determine the role of RFSs on spatial learning and memory and the properties of spontaneous hippocampal signals.

Methods

A hippocampus-dependent active avoidance task was used to assess spatial learning and memory in adult rats that underwent experimental RFSs (eRFSs) in early life compared with their littermate controls. Following completion of the task, we utilized high-density laminar probes to measure spontaneous hippocampal CA1

SUBMITTER: Kloc ML 

PROVIDER: S-EPMC8900210 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature