Brief Report: Differences in Types of Myocardial Infarctions Among People Aging With HIV.

ABSTRACT:

Background

Type 1 myocardial infarctions (T1MIs) result from atherosclerotic plaque instability, rupture, and/or erosion. Type 2 MIs (T2MIs) are secondary to causes such as sepsis and cocaine-induced vasospasm resulting in an oxygen demand-supply mismatch and are associated with higher mortality than T1MIs. T2MIs account for a higher proportion of MIs among people living with HIV (PLWH) compared with the general population. We compared MI rates by type among aging PLWH. We hypothesized that increases in MI rates with older age would differ by MI types, and T2MIs would be more common than T1MIs in younger individuals.

Methods

Potential MIs from 6 sites were centrally adjudicated using physician notes, electrocardiograms, procedure results, and laboratory results. Reviewers ca

SUBMITTER: Crane HM 

PROVIDER: S-EPMC8900222 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature