Central Nervous System Vasculopathy in HIV-Infected Children Enrolled in the Pediatric AIDS Clinical Trials Group 219/219C Study.

ABSTRACT:

Background

Central nervous system (CNS) vasculopathy has been reported in human immunodeficiency virus-infected (HIV+) adults and children. In children, it often presents with HIV encephalopathy, stroke, or intracerebral aneurysms. The etiology, incidence, and risk factors of HIV-associated CNS vasculopathy in children are unknown.

Methods

We identified HIV+ children with a diagnosis of vasculopathy or other cerebrovascular events among children enrolled between 1993 and 2004 in 2 prospective, multicenter cohort studies. Demographic and laboratory data, history of antiretroviral use, and signs, symptoms, and diagnostic studies pertaining to the CNS event were reviewed.

Results

Among the 3338 HIV+ children, 51 had diagnoses that suggested CNS vasculopathy. Of these, 12

SUBMITTER: Schieffelin JS 

PROVIDER: S-EPMC8900258 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature