The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.

ABSTRACT: RNA processing is increasingly recognized as a critical control point in the regulation of different hematopoietic lineages including megakaryocytes responsible for the production of platelets. Platelets are anucleate cytoplasts that contain a rich repertoire of RNAs encoding proteins with essential platelet functions derived from the parent megakaryocyte. It is largely unknown how RNA binding proteins contribute to the development and functions of megakaryocytes and platelets. We show that serine-arginine-rich splicing factor 3 (SRSF3) is essential for megakaryocyte maturation and generation of functional platelets. Megakaryocyte-specific deletion of Srsf3 in mice led to macrothrombocytopenia characterized by megakaryocyte maturation arrest, dramatically reduced platelet counts, and abnor

SUBMITTER: Heazlewood SY 

PROVIDER: S-EPMC8900270 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature