Ontology highlight
ABSTRACT:
SUBMITTER: Qazilbash MH
PROVIDER: S-EPMC8900281 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Qazilbash Muzaffar H MH Saini Neeraj Y NY Cha Soung-Chul SC Wang Zhe Z Stadtmauer Edward A EA Baladandayuthapani Veerabhadran V Lin Heather H Tross Beryl B Honhar Medhavi M Rao Sheetal S SS Kim Kunhwa K Popescu Michael M Szymura Szymon S Zhang Tiantian T Anderson Aaron A Bashir Qaiser Q Shpall Elizabeth J EJ Orlowski Robert Z RZ Levine Bruce L BL Kerr Naseem N Garfall Alfred A Cohen Adam A Vogl Dan T DT Dengel Karen K June Carl H CH Champlin Richard R Kwak Larry W LW
Blood 20220301 9
We hypothesized that combining adoptively transferred autologous T cells with a cancer vaccine strategy would enhance therapeutic efficacy by adding antimyeloma idiotype (Id)-keyhole limpet hemocyanin (KLH) vaccine to vaccine-specific costimulated T cells. In this randomized phase 2 trial, patients received either control (KLH only) or Id-KLH vaccine, autologous transplantation, vaccine-specific costimulated T cells expanded ex vivo, and 2 booster doses of assigned vaccine. In 36 patients (KLH, ...[more]