Construction of a new immune-related lncRNA model and prediction of treatment and survival prognosis of human colon cancer.

ABSTRACT:

Background

An increasing number of studies have shown that immune-related long noncoding RNAs (lncRNAs) do not require a unique expression level. This finding may help predict the survival and drug sensitivity of patients with colon cancer.

Methods

We retrieved original transcriptome and clinical data from The Cancer Genome Atlas (TCGA), sorted the data, differentiated mRNAs and lncRNAs, and then downloaded immune-related genes. Coexpression analysis predicted immune-related lncRNAs (irlncRNAs) and univariate analysis identified differentially expressed irlncRNAs (DEirlncRNAs). We have also amended the lasso pending region. Next, we compared the areas under the curve (AUCs), counted the Akaike information standard (AIC) value of the 3-year receiver operating characteristic (

SUBMITTER: Liu S 

PROVIDER: S-EPMC8900415 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature