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Ciprofloxacin salt and salt co-crystal with di-hydroxy-benzoic acids.

ABSTRACT: The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo-propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb--oxy-lic acid], a fluoro-quinolone anti-biotic, namely, ciprofloxacin 2,6-di-hydroxy-benzoate salt, C₁₇H₁₉FN₃O₃ ⁺·C₇H₅O₄ ^-, (I), and ciprofloxacin hydro-chloride-3,5-di-hydroxy-benzoic-water (1/1/1), C₁₇H₁₉FN₃O₃ ⁺·Cl^-·C₇H₆O₄·H₂O, (II), were determined. In (I) and (II), the ciprofloxacin cations are connected via head-to-tail N-H⋯O hydrogen bonding. Both structures show an alternating layered arrangement between ciprofloxacin and di-hydroxy-benzoic acid.

SUBMITTER: Nugraha YP

PROVIDER: S-EPMC8900500 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature

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Ciprofloxacin salt and salt co-crystal with di-hydroxy-benzoic acids.

Nugraha Yuda Prasetya YP Sugiyama Haruki H Uekusa Hidehiro H

Acta crystallographica. Section E, Crystallographic communications 20220203 Pt 3

The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo-propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb--oxy-lic acid], a fluoro-quinolone anti-biotic, namely, ciprofloxacin 2,6-di-hydroxy-benzoate salt, C17H19FN3O3 +·C7H5O4 -, (I), and ciprofloxacin hydro-chloride-3,5-di-hydroxy-benzoic-water (1/1/1), C17H19FN3O<sub ...[more]

PMID: 35371545

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