A systematic review of the methodological quality of economic evaluations in genetic screening and testing for monogenic disorders.

ABSTRACT:

Purpose

Understanding the value of genetic screening and testing for monogenic disorders requires high-quality, methodologically robust economic evaluations. This systematic review sought to assess the methodological quality among such studies and examined opportunities for improvement.

Methods

We searched PubMed, Cochrane, Embase, and Web of Science for economic evaluations of genetic screening/testing (2013-2019). Methodological rigor and adherence to best practices were systematically assessed using the British Medical Journal checklist.

Results

Across the 47 identified studies, there were substantial variations in modeling approaches, reporting detail, and sophistication. Models ranged from simple decision trees to individual-level microsimulations that compared b

SUBMITTER: Johnson K 

PROVIDER: S-EPMC8900524 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature