Effects of viremia and CD4 recovery on gut "microbiome-immunity" axis in treatment-naive HIV-1-infected patients undergoing antiretroviral therapy.

ABSTRACT:

Background

Human immunodeficiency virus type 1 (HIV-1) infection is characterized by persistent systemic inflammation and immune activation, even in patients receiving effective antiretroviral therapy (ART). Converging data from many cross-sectional studies suggest that gut microbiota (GM) changes can occur throughout including human immunodeficiency virus (HIV) infection, treated by ART; however, the results are contrasting. For the first time, we compared the fecal microbial composition, serum and fecal microbial metabolites, and serum cytokine profile of treatment-naïve patients before starting ART and after reaching virological suppression, after 24 wk of ART therapy. In addition, we compared the microbiota composition, microbial metabolites, and cytokine profile of pati

SUBMITTER: Russo E 

PROVIDER: S-EPMC8900548 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature