Association of Midlife Depressive Symptoms with Regional Amyloid-β and Tau in the Framingham Heart Study.

ABSTRACT:

Background

Depressive symptoms predict increased risk for dementia decades before the emergence of cognitive symptoms. Studies in older adults provide preliminary evidence for an association between depressive symptoms and amyloid-β (Aβ) and tau accumulation. It is unknown if similar alterations are observed in midlife when preventive strategies may be most effective.

Objective

The study aim was to evaluate the association between depressive symptoms and cerebral Aβ and tau in a predominately middle-aged cohort with examination of the apolipoprotein (APOE) ɛ4 allele as a moderator.

Methods

Participants included 201 adults (mean age 53±8 years) who underwent 11C-Pittsburgh Compound B amyloid and 18F-Flortaucipir tau positron emission tomography (PET) imaging. Depressiv

SUBMITTER: Gonzales MM 

PROVIDER: S-EPMC8900661 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature