Fascin regulates protrusions and delamination to mediate invasive, collective cell migration in vivo.

ABSTRACT:

Background

The actin bundling protein Fascin is essential for developmental cell migrations and promotes cancer metastasis. In addition to bundling actin, Fascin has several actin-independent roles; how these other functions contribute to cell migration remains unclear. Border cell migration during Drosophila oogenesis provides an excellent model to study Fascin's various roles during invasive, collective cell migration.

Results

On-time border cell migration during Stage 9 requires Fascin (Drosophila Singed). Fascin functions not only within the migrating border cells, but also within the nurse cells, the substrate for this migration. Fascin genetically interacts with the actin elongation factor Enabled to promote on-time Stage 9 migration and overexpression of Enabled suppr

SUBMITTER: Lamb MC 

PROVIDER: S-EPMC8900984 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature