Biobehavioral organization shapes the immune epigenome in infant rhesus Macaques (Macaca mulatta).

ABSTRACT: How individuals respond to and cope with stress is linked with their health and well-being. It is presumed that early stress responsiveness helps shape the health of the developing organism, but the relationship between stress responsiveness and early immune function during development is not well-known. We hypothesized that stress responsiveness may shape epigenetic regulation of immune genes in infancy. We investigated whether aspects of behavioral responsiveness and hypothalamic-pituitary adrenal stress-response were associated with epigenome-wide immune cell DNA methylation patterns in 154 infant rhesus monkeys (3-4 months old). Infants' behavioral and physiological responses were collected during a standardized biobehavioral assessment, which included temporary relocation and separati

SUBMITTER: Baxter A 

PROVIDER: S-EPMC8901048 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature