Low PrEP adherence despite high retention among transgender women in Brazil: the PrEParadas study.

ABSTRACT:

Introduction

We aimed to evaluate daily oral pre-exposure prophylaxis (PrEP) uptake, retention, and adherence and predictors of study non-attendance and low PrEP adherence in a Brazilian trans-specific 48-week study (PrEParadas).

Methods

We enrolled transgender women (TGW) engaging in high-risk sexual behaviours between August 2017 and December 2018. PrEP adherence was based on tenofovir diphosphate concentrations in dried blood spots (DBS). We used random effects logistic regression models and ordinal models to estimate the odds of having a missed visit and of low PrEP adherence, respectively. Multivariable models were adjusted for variables with p-value<0.10 in the univariate analysis.

Results

From the 271 eligible, 130 participants were enrolled in the study (PrEP

SUBMITTER: Jalil EM 

PROVIDER: S-EPMC8901149 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature