Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs.

ABSTRACT: The olfactory bulb (OB), the first relay for odor processing in the brain, receives dense GABAergic and cholinergic long-range projections from basal forebrain (BF) nuclei that provide information about the internal state and behavioral context of the animal. However, the targets, impact, and dynamic of these afferents are still unclear. How BF synaptic inputs modulate activity in diverse subtypes of periglomerular (PG) interneurons using optogenetic stimulation and loose cell-attached or whole-cell patch-clamp recording in OB slices from adult mice were studied in this article. GABAergic BF inputs potently blocked PG cells firing except in a minority of calretinin-expressing cells in which GABA release elicited spiking. Parallel cholinergic projections excited a previously overlooked PG c

SUBMITTER: De Saint Jan D 

PROVIDER: S-EPMC8901171 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature