How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition.

ABSTRACT: The stochastic expression of fewer than 60 clustered protocadherin (cPcdh) isoforms provides diverse identities to individual vertebrate neurons and a molecular basis for self-/nonself-discrimination. cPcdhs form chains mediated by alternating cis and trans interactions between apposed membranes, which has been suggested to signal self-recognition. Such a mechanism requires that cPcdh cis dimers form promiscuously to generate diverse recognition units, and that trans interactions have precise specificity so that isoform mismatches terminate chain growth. However, the extent to which cPcdh interactions fulfill these requirements has not been definitively demonstrated. Here, we report biophysical experiments showing that cPcdh cis interactions are promiscuo

SUBMITTER: Goodman KM 

PROVIDER: S-EPMC8901172 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature