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ABSTRACT: Objectives
In pandemic conditions, patients with febrile neutropenia are also at risk of COVID-19. Aim of this systematic review is to evaluate COVID-19 cases presented with febrile neutropenia and provide information regarding incidence, clinical course and prognosis.Methods
We systematically searched on COVID-19 and febrile neutropenia cases in PubMed, SCOPUS and Web of Science.Results
A total of 19 febrile neutropenic patients were analyzed. A male predominance was noted. Eleven cases had hematological malignancies. Fourteen of the cases were previously received chemotherapy. Five patients had severe neutropenia: 3 had hematologic cancer and none died. 17 (89.5%) cases have pulmonary involvement and seven of them had severe disease with acute respiratory distress syndrome (ARDS). Three cases with ARDS were died. 12 of them received G-CSF for treatment. Five cases were developed respiratory failure after G-CSF use. Overall mortality was 15.8%, while death was not observed in patients without malignancy and solid organ tumors, the mortality rate was 27% in cases with hematological malignancies.Conclusion
In ongoing pandemic, febrile neutropenic patients should be precisely evaluated for COVID-19 disease. It should be remembered that there may not be typical signs and symptoms and laboratory findings of COVID-19 disease because of the immunosuppression.
SUBMITTER: Kaya T
PROVIDER: S-EPMC8901240 | biostudies-literature | 2022 May-Jun
REPOSITORIES: biostudies-literature
Kaya Taner T Dilek Ahmet A Ozaras Resat R Balcik Ozlem Sahin OS Leblebicioglu Hakan H
Travel medicine and infectious disease 20220307
<h4>Objectives</h4>In pandemic conditions, patients with febrile neutropenia are also at risk of COVID-19. Aim of this systematic review is to evaluate COVID-19 cases presented with febrile neutropenia and provide information regarding incidence, clinical course and prognosis.<h4>Methods</h4>We systematically searched on COVID-19 and febrile neutropenia cases in PubMed, SCOPUS and Web of Science.<h4>Results</h4>A total of 19 febrile neutropenic patients were analyzed. A male predominance was not ...[more]