Efficacy of statins on renal function in patients with chronic kidney disease: a systematic review and meta-analysis.

ABSTRACT:

Background

Studies have shown that the use of statins could significantly improve lipid profiles; however, it remains controversial whether the use of statins could improve renal function in patients with chronic kidney disease (CKD). Therefore, we conducted a meta-analysis of randomized controlled trials (RCTs) to evaluate the effects of statins on renal function in patients with CKD.

Methods

We systematically searched PubMed, EMBASE, and the Cochrane Library databases for eligible RCTs from inception to October 2020. Pooled effect estimates were assigned as weighted mean differences (WMDs) with 95% confidence intervals (CIs) using the random-effects model.

Results

We selected 33 RCTs that recruited 37,391 patients with CKD patients. The summary results suggested tha

SUBMITTER: Zhao L 

PROVIDER: S-EPMC8901279 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature