FoxK1 is Required for Ectodermal Cell Differentiation During Planarian Regeneration.

ABSTRACT: Forkhead box (Fox) genes belong to the "winged helix" transcription factor superfamily. The function of some Fox genes is well known, such as the role of foxO in controlling metabolism and longevity and foxA in controlling differentiation of endodermal tissues. However, the role of some Fox factors is not yet well characterized. Such is the case of FoxK genes, which are mainly studied in mammals and have been implicated in diverse processes including cell proliferation, tissue differentiation and carcinogenesis. Planarians are free-living flatworms, whose importance in biomedical research lies in their regeneration capacity. Planarians possess a wide population of pluripotent adult stem cells, called neoblasts, which allow them to regenerate any body part after injury. In a r

SUBMITTER: Coronel-Cordoba P 

PROVIDER: S-EPMC8901602 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature