Advancements of Common Gamma-Chain Family Cytokines in Cancer Immunotherapy.

ABSTRACT: The approval of immunotherapies such as checkpoint inhibitors (CPIs), adoptive cell therapies and cancer vaccines has revolutionized the way cancer treatment is approached. While immunotherapies have improved clinical outcome in a variety of tumor types, some cancers have proven harder to combat using single agents, underscoring the need for multi-targeted immunotherapy approaches. Efficacy of CPIs and cancer vaccines requires patients to have a competent immune system with adequate cell numbers while the efficacy of adoptive cellular therapy is limited by the expansion and persistence of cells after infusion. A promising strategy to overcome these challenges is combination treatment with common gamma-chain cytokines. Gamma-chain cytokines play a critical role in the survival, proliferatio

SUBMITTER: Wolfarth AA 

PROVIDER: S-EPMC8901704 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature