Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites.

ABSTRACT: The World Health Organization determined cardiovascular disease to be the leading cause of death globally; atherosclerosis is the primary cause of the high morbidity and mortality rates. Regular physical activity is an effective strategy for maintaining endothelial health and function to prevent the development of atherosclerosis. Obesity is also a crucial risk factor for atherosclerotic progression in combination with various complications and systemic inflammation. Physiological homeostasis is modulated by the intestinal microbiota, but the mechanisms through which exercise attenuates atherosclerosis through the microbiota have not been elucidated. Therefore, we investigated the effects of endurance exercise on atherosclerosis induced by a Western diet (WD) and apolipoprotein E (ApoE) kn

SUBMITTER: Huang WC 

PROVIDER: S-EPMC8901804 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature