Melatonin abolished proinflammatory factor expression and antagonized osteoarthritis progression in vivo.

ABSTRACT: Progressive structural changes in osteoarthritis (OA) involve synovial inflammation and angiogenesis, as well as activation of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α) and interleukin (IL)-8, and the angiogenic factor vascular endothelial growth factor (VEGF). The endogenous hormone melatonin (N-acetyl-5-methoxytryptamine) is involved in antioxidative and anti-inflammatory activities, but how it antagonizes OA progression via its specific receptors is unclear. Here, we demonstrate that the MT₁ melatonin receptor, but not the MT₂ receptor, is highly expressed in normal tissue and only minimally in OA tissue. By targeting the MT₁ receptor, melatonin reversed OA-induced pathology and effectively reduced levels of TNF-α, IL-8, and VEGF

SUBMITTER: Liu SC 

PROVIDER: S-EPMC8901806 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature