Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus.

ABSTRACT:

Background

Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles. As it is often difficult to prove repositioning candidates' effectiveness in real-world clinical settings, we used patient-centered real-world data for screening repositioning candidate drugs for multiple diseases simultaneously, especially for diabetic complications.

Methods

Using the National Health Insurance Service-National Sample Cohort (2002 to 2013), we analyzed claims data of 43,048 patients with type 2 diabetes mellitus (age ≥40 years). To find repositioning candidate disease-drug pairs, a nested case-control study was used for 29 pairs of diabetic complications and the drugs that met our criteria.

SUBMITTER: Park N 

PROVIDER: S-EPMC8901955 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature