Anticoagulation Strategies in Critically Ill Patients With SARS-CoV-2 Infection: The Role of Direct Thrombin Inhibitors.

ABSTRACT:

Objectives

To compare heparin-based anticoagulation and bivalirudin-based anticoagulation within the context of critically ill patients with a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Design

An observational study.

Setting

At the intensive care unit of a university hospital.

Participants and interventions

Critically ill patients with a SARS-CoV-2 infection receiving full anticoagulation with heparin or bivalirudin.

Measurements and main results

Twenty-three patients received full anticoagulation with bivalirudin and 60 with heparin. Despite patients in the bivalirudin group having higher mortality risk scores (SAPS II 60 ± 16 v 39 ±7, p < 0.001) and a higher need for extracorporeal support compared to the heparin group, hos

SUBMITTER: Pieri M 

PROVIDER: S-EPMC8902052 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature