Exploration of radiation-induced lung injury, from mechanism to treatment: a narrative review.

ABSTRACT:

Background and objective

Radiation-induced lung injury (RILI) is often found in thoracic tumor patients after thoracic radiation therapy, and influences patient quality of life. However, systematic exploration of RILI, including its molecular biological mechanisms and standardized treatment, has not yet been fully elucidated. The main objective of the narrative review was to describe the available evidence concerning RILI, from the biological mechanism to the clinical management. The underlying causes of RILI are multifactorial, including gene-level changes, the influence of signaling pathways, the convergence of various cells, as well as the expression of cytokines and chemokines. Based on the various mechanisms of RILI, several novel treatment strategies have been proposed and gr

SUBMITTER: Yan Y 

PROVIDER: S-EPMC8902083 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature