Hypofractionated vs. standard radiotherapy for locally advanced limited-stage small cell lung cancer.

ABSTRACT:

Background

Hypofractionated radiotherapy in locally advanced limited-stage small cell lung cancer is preferred in many Western countries but not used regularly in the United States. We examined practice patterns and overall survival with definitive hypofractionated radiotherapy and chemotherapy vs. standard radiotherapy in this setting.

Methods

We included patients in the National Cancer Database with unresected primary stage II-III small cell lung cancer in 2008-2016 who underwent chemotherapy within six months of either hypofractionated radiotherapy (40-45 Gy/15 fractions) or standard radiotherapy (45 Gy/30 fractions or 60-70 Gy/30-35 fractions) in this retrospective cohort study. Patient characteristics were assessed with univariable and multivariable logistic regr

SUBMITTER: Saeed NA 

PROVIDER: S-EPMC8902118 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature