Between-Subject and Within-Subject Variaton of Muscle Atrophy and Bone Loss in Response to Experimental Bed Rest.

ABSTRACT: To improve quantification of individual responses to bed rest interventions, we analyzed peripheral quantitative computer tomography (pQCT) datasets of the lower leg of 76 participants, who took part in eight different bed rest studies. A newly developed statistical approach differentiated measurement uncertainty U _Meas from between-subject-variation (BSV) and within-subject variation (WSV). The results showed that U _Meas decreased 59.3-80% over the two decades of bed rest studies (p < 0.01), and that it was higher for muscles than for bones. The reduction of U _Meas could be explained by improved measurement procedures as well as a higher standardization. The vast majority (89.6%) of the individual responses

SUBMITTER: Bocker J 

PROVIDER: S-EPMC8902302 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature