Immunological Subsets Characterization in Newly Diagnosed Relapsing-Remitting Multiple Sclerosis.

ABSTRACT:

Objectives

Using flow cytometry, we characterized myeloid, B, and T cells in patients recently diagnosed with relapsing-remitting multiple sclerosis (RRMS) naive to disease-modifying therapies (DMTs).

Methods

This prospective case-control study was conducted in the tertiary MS center of Catania, Italy. Demographic/clinical data and peripheral bloods were collected from 52 naive patients recently diagnosed with RRMS and sex/age-matched healthy controls (HCs) in a 2:1 ratio. We performed flow cytometry on isolated peripheral blood mononuclear cells to assess immune cell subsets differences between RMMS patients and HCs. We explored the biomarker potential of cell subsets using receiver operating characteristic (ROC) curves and relative area under the curve (AUC) analyses.

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SUBMITTER: D'Amico E 

PROVIDER: S-EPMC8902351 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature