Lactobacillus crispatus Strain KT-11 S-Layer Protein Inhibits Rotavirus Infection.

ABSTRACT: S-layer proteins (SLPs), which are present in the external layer of certain strains of lactic acid bacteria isolated from the intestinal tract, are known to recognize and bind to specific proteins and glycan structures and contribute to adsorption to the host intestinal mucosa. The binding properties of certain SLPs are considered to exert a competitive inhibitory effect on infection because similar properties are involved in the infection mechanisms of several viruses. However, little is known regarding whether SLPs directly inhibit viral infection. In the present study, we investigated the effect of an SLP of the Lactobacillus crispatus KT-11 strain, a probiotic strain isolated from a healthy human infant, on human rotavirus infection. The impact of KT-11 lithium chloride extract

SUBMITTER: Kawahara T 

PROVIDER: S-EPMC8902352 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature