TIGIT marks exhausted T cells and serves as a target for immune restoration in patients with chronic HBV infection.

ABSTRACT:

Background

Chronic HBV infection is a serious worldwide health problem that mainly causes liver cirrhosis and hepatocellular carcinoma (HCC). Few studies have explored how T cell exhaustion helps HBV avoid immune system attack and how to reverse that exhaustion. Recently, T cell immunoglobulin and immune receptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) have been identified as coinhibitory receptors, similar to PD-1. This study explores the expression of TIGIT and the T cell function changes in patients with chronic HBV infection.

Results

In this study, we found that the expression of TIGIT on T cells increased significantly in patients with chronic HBV infection. High expression of TIGIT on T cells is associated with functional exhaustion. Importantly, this stu

SUBMITTER: Wei YY 

PROVIDER: S-EPMC8902551 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature