Clinical predictors of pulmonary tuberculosis among South African adults with HIV.

ABSTRACT:

Background

Tuberculosis (TB) clinical prediction rules rely on presence of symptoms, however many undiagnosed cases in the community are asymptomatic. This study aimed to explore the utility of clinical factors in predicting TB among people with HIV not seeking care.

Methods

Baseline data were analysed from an observational cohort of ambulant adults with HIV in South Africa. Participants were tested for Mycobacterium tuberculosis (Mtb) sensitisation (interferon-γ release assay, IGRA) and microbiologically-confirmed prevalent pulmonary TB disease at baseline, and actively surveilled for incident TB through 15 months. Multivariable LASSO regression with post-selection inference was used to test associations with Mtb sensitisation and TB disease.

Findings

Between

SUBMITTER: Mendelsohn SC 

PROVIDER: S-EPMC8902614 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature