A neurodegenerative disease landscape of rare mutations in Colombia due to founder effects.

ABSTRACT:

Background

The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed through a population bottleneck due to widespread infectious diseases that left small isolated local settlements. As a result, the current population reflects multiple founder effects derived from diverse ancestries.

Methods

We characterized the role of admixture and founder effects on the origination of the mutational landscape that led to neurodegenerative disorders under these historical circumstances. Genomes from 900 Colombian individuals with Alzheimer's disease (AD) [n = 376], frontotemporal lobar degeneration-motor neuron disease continuum (FTLD-MND) [n

SUBMITTER: Acosta-Uribe J 

PROVIDER: S-EPMC8902761 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature