Body size in early life and the risk of postmenopausal breast cancer.

ABSTRACT:

Background

Greater early life adiposity has been reported to reduce postmenopausal breast cancer risk but it is unclear whether this association varies by tumour characteristics. We aimed to assess associations of early life body size with postmenopausal breast cancer and its subtypes, allowing for body size at other ages.

Methods

A total of 342,079 postmenopausal UK women who reported their body size at age 10, clothes size at age 20, and body mass index (BMI) at baseline (around age 60) were followed by record linkage to national databases for cancers and deaths. Cox regression yielded adjusted relative risks (RRs) of breast cancer, overall and by tumour subtype, in relation to body size at different ages.

Results

During an average follow-up of 14 years, 15,506 brea

SUBMITTER: Yang TO 

PROVIDER: S-EPMC8902765 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature