Chronic corticosterone disrupts the circadian rhythm of CRH expression and m⁶A RNA methylation in the chicken hypothalamus.

ABSTRACT:

Background

Corticotropin-releasing hormone (CRH), the major secretagogue of the hypothalamic-pituitary-adrenal (HPA) axis, is intricately intertwined with the clock genes to regulate the circadian rhythm of various body functions. N6-methyladenosine (m⁶A) RNA methylation is involved in the regulation of circadian rhythm, yet it remains unknown whether CRH expression and m⁶A modification oscillate with the clock genes in chicken hypothalamus and how the circadian rhythms change under chronic stress.

Results

Chronic exposure to corticosterone (CORT) eliminated the diurnal patterns of plasma CORT and melatonin levels in the chicken. The circadian rhythms of clock genes in hippocampus, hypothalamus and pituitary are all disturbed to different extent in CORT

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8902767 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature