Vaginal Microbiota Changes in Patients With Premature Ovarian Insufficiency and Its Correlation With Ovarian Function.

ABSTRACT:

Objectives

To reveal the characteristics of vaginal microbiota in premature ovarian insufficiency (POI) patients and their relationship with ovarian function.

Materials and methods

In this case-control study, the vaginal bacterial composition of 30 POI patients and 26 healthy women of comparable age was assessed by 16S rRNA gene sequencing targeting the V3-V4 hypervariable regions. The metabolic functions of vaginal microflora were preliminarily predicted through the PICRUSt2 analysis. Redundancy analysis and Spearman's correlation analyzed the relationships between vaginal microbiota and ovarian function indicators.

Results

Actinobacteria, Atopobium, and Gardnerella were significantly increased in POI patients. Their increments were significantly

SUBMITTER: Wen J 

PROVIDER: S-EPMC8902819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature