Transcriptomic analysis reveals myometrial topologically associated domains linked to the onset of human term labour.

ABSTRACT: Changes in cell phenotype are thought to occur through the expression of groups of co-regulated genes within topologically associated domains (TADs). In this paper, we allocate genes expressed within the myometrium of the human uterus during the onset of term labour into TADs. Transformation of the myometrial cells of the uterus into a contractile phenotype during term human labour is the result of a complex interaction of different epigenomic and genomic layers. Recent work suggests that the transcription factor (TF) RELA lies at the top of this regulatory network. Using deep RNA sequencing (RNAseq) analysis of myometrial samples (n = 16) obtained at term from women undergoing caesarean section prior to or after the onset of labour, we have identified evidence for how other gene expressio

SUBMITTER: Tyagi S 

PROVIDER: S-EPMC8903000 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature