Change in Cardiac Biomarkers and Risk of Incident Heart Failure and Atrial Fibrillation in CKD: The Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Circulating cardiac biomarkers may signal potential mechanistic pathways involved in heart failure (HF) and atrial fibrillation (AF). Single measures of circulating cardiac biomarkers are strongly associated with incident HF and AF in chronic kidney disease (CKD). We tested the associations of longitudinal changes in the N-terminal fragment of the prohormone brain natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hsTnT), galectin-3, growth differentiation factor 15 (GDF-15), and soluble ST-2 (sST-2) with incident HF and AF in patients with CKD.

Study design

Observational, case-cohort study design.

Setting & participants

Adults with CKD enrolled in the Chronic Renal Insufficiency Cohort study.

Exposures

Biomarkers were measured

SUBMITTER: Bansal N 

PROVIDER: S-EPMC8903040 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature