Gene-Environment Interactions for Cardiovascular Disease.

ABSTRACT:

Purpose of review

We provide an overview of recent findings with respect to gene-environment (GxE) interactions for cardiovascular disease (CVD) risk and discuss future opportunities for advancing the field.

Recent findings

Over the last several years, GxE interactions for CVD have mostly been identified for smoking and coronary artery disease (CAD) or related risk factors. By comparison, there is more limited evidence for GxE interactions between CVD outcomes and other exposures, such as physical activity, air pollution, diet, and sex. The establishment of large consortia and population-based cohorts, in combination with new computational tools and mouse genetics platforms, can potentially overcome some of the limitations that have hindered human GxE interaction studies and

SUBMITTER: Hartiala JA 

PROVIDER: S-EPMC8903169 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature