Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis.

ABSTRACT:

Background

The incidence of multidrug-resistant tuberculosis (MDR-TB) remains critically high in countries of the former Soviet Union, where >20% of new cases and >50% of previously treated cases have resistance to rifampin and isoniazid. Transmission of resistant strains, as opposed to resistance selected through inadequate treatment of drug-susceptible tuberculosis (TB), is the main driver of incident MDR-TB in these countries.

Methods and findings

We conducted a prospective, genomic analysis of all culture-positive TB cases diagnosed in 2018 and 2019 in the Republic of Moldova. We used phylogenetic methods to identify putative transmission clusters; spatial and demographic data were analyzed to further describe local transmission of Mycobacterium tuberculosis. Of 2,236 pa

SUBMITTER: Yang C 

PROVIDER: S-EPMC8903246 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature