Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients.

ABSTRACT:

Background

Vitamin D deficiency has been associated with worse coronavirus disease 2019 (COVID-19) outcomes, but circulating 25-hydroxyvitamin D [25(OH)D] is largely bound to vitamin D-binding protein (DBP) or albumin, both of which tend to fall in illness, making the 25(OH)D status hard to interpret. Because of this, measurements of unbound ("free") and albumin-bound ("bioavailable") 25(OH)D have been proposed.

Objectives

We aimed to examine the relationship between vitamin D status and mortality from COVID-19.

Methods

In this observational study conducted in Liverpool, UK, hospitalized COVID-19 patients with surplus sera available for 25(OH)D analysis were studied. Clinical data, including age, ethnicity, and comorbidities, were extracted from case notes. Serum 25(O

SUBMITTER: Subramanian S 

PROVIDER: S-EPMC8903333 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature