Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm.

ABSTRACT:

Background

Although survival rates for infants born extremely preterm (gestation < 28 weeks) have improved significantly in recent decades, neurodevelopmental impairment remains a major concern. Children born extremely preterm remain at high risk for cognitive impairment from early childhood to adulthood. However, there is limited evidence on genetic factors associated with cognitive impairment in this population.

Methods

First, we used a latent profile analysis (LPA) approach to characterize neurocognitive function at age 10 for children born extremely preterm. Children were classified into two groups: (1) no or low cognitive impairment, and (2) moderate-to-severe cognitive impairment. Second, we performed TOPMed-based genotype imputation on samples with genotype array data

SUBMITTER: Liu W 

PROVIDER: S-EPMC8903548 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature