Immune-Related Long Non-coding RNA Constructs a Prognostic Signature of Ovarian Cancer.

ABSTRACT:

Background

Since ovarian cancer leads to the poor prognosis in women all over the world, we aim to construct an immune-related lncRNAs signature to improve the survival of ovarian cancer patients.

Methods

Normal and cancer patient samples and corresponding clinical data of ovarian were obtained from The Genotype-Tissue Expression (GTEx) portal and The Cancer Genome Atlas (TCGA) database. The predictive signature was constructed by the lasso penalty Cox proportional hazard regression model. The division of different risk groups was accounting for the optimal critical value of the time-dependent Receiver Operating Characteristic (ROC) curve. Finally, we validated and evaluated the application of this prognostic signature based on the clinical factors, chemo-sensitivity and imm

SUBMITTER: Sun X 

PROVIDER: S-EPMC8903634 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature