Identification of biomarkers of chronic kidney disease among kidney-derived proteins.

ABSTRACT:

Background

Chronic kidney disease (CKD) has few objective symptoms, and it is difficult to make an early diagnosis by using existing methods. Therefore, new biomarkers enabling diagnosis of renal dysfunction at an early stage need to be developed. Here, we searched for new biomarkers of CKD by focusing on kidney-derived proteins that could sensitively reflect that organ's disease state.

Methods

To identify candidate marker proteins, we performed a proteomics analysis on renal influx and efflux blood collected from the same individual.

Results

Proteomics analysis revealed 662 proteins in influx blood and 809 in efflux. From these identified proteins, we selected complement C1q as a candidate; the plasma C1q level was significantly elevated in the renal efflux of donors

SUBMITTER: Higashisaka K 

PROVIDER: S-EPMC8903635 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature