Cell factory for γ-aminobutyric acid (GABA) production using Bifidobacterium adolescentis.

ABSTRACT:

Background

Bifidobacteria are gram-positive, probiotic, and generally regarded as safe bacteria. Techniques such as transformation, gene knockout, and heterologous gene expression have been established for Bifidobacterium, indicating that this bacterium can be used as a cell factory platform. However, there are limited previous reports in this field, likely because of factors such as the highly anaerobic nature of this bacterium. Bifidobacterium adolescentis is among the most oxygen-sensitive Bifidobacterium species. It shows strain-specific gamma-aminobutyric acid (GABA) production. GABA is a potent bioactive compound with numerous physiological and psychological functions. In this study, we investigated whether B. adolesentis could be used for mass production of GABA.

Results<

SUBMITTER: Altaib H 

PROVIDER: S-EPMC8903651 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature