Mitochondrial potassium channels: A novel calcitriol target.

ABSTRACT:

Background

Calcitriol (an active metabolite of vitamin D) modulates the expression of hundreds of human genes by activation of the vitamin D nuclear receptor (VDR). However, VDR-mediated transcriptional modulation does not fully explain various phenotypic effects of calcitriol. Recently a fast non-genomic response to vitamin D has been described, and it seems that mitochondria are one of the targets of calcitriol. These non-classical calcitriol targets open up a new area of research with potential clinical applications. The goal of our study was to ascertain whether calcitriol can modulate mitochondrial function through regulation of the potassium channels present in the inner mitochondrial membrane.

Methods

The effects of calcitriol on the potassium ion current were measure

SUBMITTER: Olszewska AM 

PROVIDER: S-EPMC8903690 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature