Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND).

ABSTRACT:

Background

Tuberous Sclerosis Complex (TSC) is associated with a range of neuropsychiatric difficulties, appropriately termed TSC-Associated Neuropsychiatric Disorders (TAND). The objectives of the study were to analyze the rates of TAND symptoms in a cohort of patients seen at the TSC Center of Excellence at Cincinnati Children's Hospital and to identify clinically meaningful profiles based on TAND symptoms.

Methods

Data from the TAND Checklist was obtained from participants seen at the TSC Center of Excellence at Cincinnati Children's Hospital Medical Center from June 2015 to August 2018. Cluster and factor analyses for each TAND symptom were performed. Factor scores were then calculated for participants, and a K-means cluster analysis of these scores was used to empirical

SUBMITTER: Alperin S 

PROVIDER: S-EPMC8903711 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature